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Diet, The Immune System, and Prostate Cancer Prostate cancer is the most frequent cancer occurring in males , and the 2nd leading cause of death due to cancer in males, trailing only lung cancer. Risk Factors for Prostate Cancer Age: As men get older, the risk factor for developing prostate cancer increases dramatically . The chance of developing the disease dramatically increases at the age of 55.Race:
The risk of prostate cancer is dramatically higher among blacks , intermediate among whites, and the risk of the disease is lowest among native Japanese. This increase in risk may be due to other factors that are associated with race, and not race itself. Blacks in Africa do not have the same high rate of prostate cancer and mortality as blacks in the United States. Lower levels of vitamin D may contribute to the higher rates of prostate cancer in African American men in the United States, and prostate cancer incidence increases in northern latitudes like the USA and Canada where total sun exposure is significantly less than equitorial Africa, resulting in less natural production of vitamin D. Additionally, sun exposure in early childhood also protects against the future development of prostate cancer , and a protective link may exist between exposure to ultraviolet radiation and development of prostate cancer, as patients diagnosed with skin cancer are less likely to develop prostate cancer . Studies have shown a link between levels of testosterone associations with high testosterone levels are not consistent in all clinical studies or meta-analyses of testosterone levels and prostate cancer risk . Black men have the highest levels of serum testosterone, whites are intermediate, and Japanese men tend to have lower levels.Diet:
Animal Fats and Red Meats: Many studies suggest that a diet high in saturated animal fat , processed meats , red meat , and certain vegetable oils may contribute to prostate cancer. One study found that Alpha Linoleic acid intake was associated with the development of prostate cancer , but EPA (fish oil) was protective. Another study found no relationship with aphpa linoleic acid consumption and the subsequent risk of prostate cancer .
Glutathione: Glutathione may have a protective role in prostate cancer.
Glutathione may suppress both suppresses prostate cancer growth and metastasis.
Non fat milk: A diet rich in non-fat milk may also increase the risk of prostate cancer, whereas lycopene from tomatoes may reduce the risk . A larger study published in the American Journal of Epidemiology in December, 2007 confirmed this association of high skim milk consumption and death from prostate cancer. Studies are being conducted to further validate this association of skim milk and prostate cancer .
Lycopene: Research has validated a protective effect against prostate cancer associated with tomato (or lycopene) consumption in both population-based studies, clinical studies and meta-analyses .
Red wine, grapes and resveratrol: Resveratrol (found in grape skins and in red wine) may reduce the risk of prostate cancer. This research on the beneficial effect of resveratrol in prostate cancer has been replicated in population studies and in the test tube .
Green Tea: Green tea consumption reduces the risk of prostate cancer and may be associated with the decreased risk in Japanese men.
Pomegranate: Pomegranate consumption may be associated with a lower risk of prostate cancer , and
Blueberries: blueberry consumption may be associated with a lower risk .
Dietary sources of vitamin E (gamma tocopherol): Dietary sources of vitamin E but not supplements were beneficial in reducing the risk of prostate cancer in one large population-based study.
Capsaicin (Red pepper): Capsaicin (from red pepper) may be associated with a reduced risk of prostate cancer .
Legumes (soy): Consumption of legumes (soyfoods, or other legumes) was inversely related to prostate cancer in one large population study.
Other foods: Additional stidies on diet and prostate cancer risk . Family History:
Genetics can play a role in whether a man develops prostate cancer. Men with a family history of prostate cancer are more likely to develop the disease . It is estimated that up to 10% of cases of prostate cancer are due to a genetic mutation that can be found in family members developing the disease. Smoking: As in many other types of cancers, smoking increases the risk of prostate cancer, and the risk of death from prostate cancer . Other studies on the association of smoking and prostate cancer .Sexual activity and infection:
Venereal diseases (STDs) and sex with prostitutes was associated with an increased risk of prostate cancer in one epidemiologic study , and prostatic infections were associated with increased risk of developing prostate cancer , however in a prospective study conducted by the National Institutes of Health using follow-up data from the Health Professionals Follow-up Study and which was published in the Journal of the American Medical Association, high ejaculation frequency was related to a decreased risk of prostate cancer .Obesity:
Although controversy exists concerning the relationship of obesity with the development of prostate cancer, data strongly suggest that obesity is a significant risk factor for death from prostate cancer .Physical Stature:
Greater adult height has been associated with increased prostate cancer risk in several observational studies . This may be due to exposure to androgens (male sex hormones), growth hormones, and other factors during growth and development, as well as due to hereditary factors.Socioeconomic status and poverty: Low socioeconomic status (SES) is associated with an increased risk of prostate cancer , but this may be due to poor diet, a higher liklihood of smoking, or other environmental or lifestyle factors that are also associated with low SES.Exercise and Physical Activity: Regular aerobic Exercise may reduce the risk of prostate cancer , slow it's progression, and reduce mortality , but the mechanism of this protection is unknown, but may be associated with the beneficial effects of exercise on insulin-like growth factor.Inflammation and inflammatory disease . Inflammatory disease, especially inflammation of the prostate, increases the risk for developing prostate cancer . Supplements with anti-inflammatory properties, and NSAIDs (non-steroidal anti-inflammatory drugs ) may reduce the risk of developing the disease. Stain drugs , which may have anti-inflammatory properties, were associated with a reduced risk of fatal or metastatic prostate cancers .
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