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Glutathione Side Effects:
There are no scientifically recognized side effects from or interactions with oral glutathione supplementation because oral glutathione supplements are not absorbed into the bloodstream in humans.
There are side effects associated with intravenous (putting glutathione directly into a vein) glutathione supplementation. Additionally some substances used to elevate glutathione levels such as N Acetyl Cystine, are associated with side effects.
Although glutathione is marketed as a nutritional supplement, there is no scientific evidence that glutathione supplements significantly increase the levels of glutathione in the blood stream or inside the cells ands tissues of the body in humans. In human studies, oral doses of glutathione had no significant effect in raising blood levels. When seven healthy people were given a single dose of 3,000 mg (a huge oral dose) of glutathione, there was no increase in blood glutathione levels. The authors of this study concluded that "it is not feasible to increase circulating glutathione to a clinically beneficial extent by the oral administrating of a single application of 3,000 mg of glutathione." Witschi A, Reddy S, Stofer B, Lauterburg BH. The systemic availability of oral glutathione. (source: Eur J Clin Pharmacol 1992;43(6):667-9) IV Glutathione is effective but it is expensive, uncomfortable, and somewhat impractical requiring infusions 2 times per week using an Intravenous (IV) line. Glutathione precursors such as Immunocal are a better solution.
Although glutathione supplements appear ineffective in humans, they are efficiently absorbed in rats. Most marketers of oral glutathione quote these rat studies as "proof" of their absorption. The successful absorption of glutathione in rats may be due to the fact that the gastrointestinal tract of rats has little or no gamma-glutamyltranspeptidase which is responsible for breaking down glutathione. The human gastrointestinal tract, however, contains significant amounts of this enzyme.
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