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01-06-99 As a clinical scientist and a certified nutritionist, I probably would have never tried Calorad® if it had not been recommended to me by my best friend, Scott.

01-10-99 Purchased and started using Calorad® for the first time.

01-17-99 Day 7 - Weight loss ...4 lbs.

01-24-99 Day 14 - I lose 4 more lbs and decide to become a distributor!

02-10-99 Day 30 - I finish my first bottle and lose .. another 4 lbs for a total of 12 pounds!

02-10-99 Day 30 I have lost almost 12 pounds and over two and a half inches off my waist within my first four weeks on Calorad®.

02-10-99 Day 30 My wife, Lynn, loses three pounds and a total of five inches in the same time period.

02-24-99 Six weeks on the product. I experience increased energy, improved sleep, and several lipofuscin deposits (age spots) on my hands recede and totally disappear.

03-03-99 My wife, who previously suffered from frequent and rather severe bouts of insomnia, now 'sleeps like a baby.'

04-07-99 My teenage son and daughter also start to use the product and experience similar weight loss and muscle toning.

05-11-99 My sister loses 10 pounds and two dress sizes in three weeks, and she loves the product.

11-07-99 I decide to spread the word online, and establish my nutrition advisor website.

As a clinical scientist with a doctorate in nutrition, I can truly say that Calorad® is one of the best diet products I've ever seen!

In the 4 1/2 years since, we have sold over $1 million dollars of Calorad® online, and have seen many great Calorad® success stories.

Sincerely, Dr. Steven Petrosino, Ph.D. (nutrition)

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Chromium Picolinate and Weight Loss

Introduction

The benefit of chromium supplementation is controversial, with some studies showing a benefit, and others showing no effect. All clinical studies using Chromium for weight loss have used 200 to 400 micrograms, or up to 25 times the amount of chromium often included in weight loss or diet supplements (usually a non-significant 15 micrograms). Gaining increased popularity in the United States, chromium has been touted a "miracle mineral", and advertised to have many beneficial effects including weight loss, mood enhancement, energy promotion, longevity, and the prevention of acne (Krzanowski, 1996). The most common use for chromium picolinate is as a weight loss aid. Claims that this supplement can "melt fat", drastically reduce appetite, and increase metabolism are rampant and account for the popularity of chromium picolinate in our diet-obsessed culture. Recently, the supplement has been marketed as a “safe alternative to steroids,” claiming to increase strength and lean muscle mass based on one small study (Trent &Thieding-Cancel, 1995). Chromium picolinate is a common ingredient in many herbal weight-loss concoctions readily available for over-the-counter sale at the local drugstore or on the internet. However, because chromium picolinate is a nutritional supplement rather than a prescription drug, the Food and Drug Administration (FDA) will not confirm the accuracy of advertiser’s often remarkable claims (Krzanowski, 1996). Additionally, scientific research is generally unsupportive of the weight loss claims surrounding chromium picolinate; consumers must be aware of these discrepancies when making a decision to take this or any other nutritional supplement. Additionally, the small studies showing beneficial effects in weight loss often used much higher doses of the mineral than the trace amounts which are contained in many weight loss preparations. Doses below 25 micrograms (common in these weight-loss preparations) are probably ineffective.

What is chromium picolinate?

This popular nutritional supplement is a combination of the element chromium and picolinic acid. Chromium is a naturally-occurring mineral, trace amounts of which are found in common foods such as meat, poultry, fish, and whole-grain breads. When foods are processed, they are stripped of natural chromium, making American diets generally very low in chromium; studies estimate an average daily chromium consumption of 33 mcg. In 1968, it was demonstrated that when animals do not receive adequate levels of chromium, insulin is not optimally effective, and damage to insulin-dependent systems can occur (Schroeder, 1968). This led the FDA to recommend a daily chromium intake of approximately 130 mcg, as infinitesimal amounts of chromium are needed to aid the transport of blood glucose across cell membranes (http://www.oznet.ksu.edu/dp_fnut/_timely/CHROMIUM.htm). Combining chromium with picolinic acid simply aids in efficient chromium absorption, and it is this combined form that is popular on the diet market today.

How does chromium picolinate work?

After eating, the human body secretes the hormone insulin. In general, the primary function of insulin is to transport glucose to the body’s cells in order to provide energy that facilitates cell functioning. It is speculated that chromium picolinate works by stimulating the activity of insulin, thus significantly aiding the body’s glucose and fat metabolism, managing the breakdown of glucose and fat (http://phys.com/b_nutrition/02solutions/08diet/chromium.htm). The exact mechanisms by which chromium improves this insulin efficiency are currently unclear; it has been suggested that chromium somehow works to increase sensitivity of insulin receptors (Krzanowski, 1996). However, because research has yet to produce any definite answers as to the exact function of chromium picolinate, competing theories about its precise effects exist. Some claim that that the improved insulin efficiency causes an increase in the production of seratonin, which subsequently reduces appetite. Still others assert that chromium can regulate the fat-production processes in the body, preventing excess fat from forming. One hypothesis states that chromium picolinate increases protein synthesis, which in turn stimulates muscle growth (http://www.parrillo.com/press/990706.HTM). Heavy marketing of chromium picolinate as a dietary aid focuses on chromium picolinate’s reputed ability to reduce the body’s fat stores while conserving lean muscle mass (http://www.getlean.net/chromium.htm).

Claims about chromium picolinate

The internet is replete with sites that laud chromium picolinate as the ultimate weight loss tool. Many of these sites market chromium picolinate as having a very specific effect on the body's energy supply, tagging the supplement “an indispensable biochemical partner of insulin” (http://www.getlean.net/chromium.htm). As such, chromium picolinate will help the dieter burn calories and control their appetite while melting away undesirable body fat. In addition to these appealing claims is the statement that chromium picolinate will increase and even tone lean muscle mass during the weight loss process. The supplement is therefore a vital addition to recent “exercise in a bottle” and herbal fat burner pills. These diet compounds, which are readily available over the internet, often combine chromium picolinate with L-carnitine (http://www.feel21.com/cgi-bin/feel21/131260?7MdTKlR4;;22), with guarana and ma huang (http://www.headstartvitamins.com/metabolite.html), or with dangerous diuretics (http://www.click-here-now.com/vitaminpower/nutratrimplus.htm). Such combination tablets are risky, as any interactions between chromium picolinate and other supplements remain unknown at this time (http://phys.com/b_nutrition/02solutions/08diet/chromium.htm). Nevertheless, chromium picolinate continues to appear as an ingredient in products with promising names like “Ripped Action,” “Fat Burner Bars,” and “Ripped Fast,” alluding to the spectacular results that a dieter might expect from chromium picolinate (http://www.bodybuilding.com/store/hp/picolinate_page.html). Weight loss is not the only effect that one can expect from chromium picolinate, however. One bodybuilding site even refers to uncited “evidence” that chromium picolinate can expand the life span via “age-slowing effects” while as improving circulation. The site’s concluding statement on the potency of chromium picolinate is simply: “whoa, that is powerful!!” (http://www.bodybuilding.com/store/hp/picolinate_page.html)

Does chromium picolinate effectively aid weight loss?

Scientific research has been largely (but not completely) unsupportive of the claims made about chromium picolinate’s ability to significantly aid weight loss. Because chromium picolinate may possess an ability to reduce fat while maintaining and increasing lean muscle mass, the most relevant studies are those examining body composition. These measurements typically include percent body fat, body weight, and lean body mass. A study by Trent and Thieding-Cancel (1995) examines the effectiveness of chromium picolinate as a fat-reduction aid in an obese subject population. In this particular study, obesity was defined as exceeding the Navy’s percent body fat standards: 22% fat for men and 30% fat for women. Over the course of the study, subjects met three times weekly for at least thirty minutes of aerobic activity; one half of the group received 400 mcg of chromium picolinate to supplement their training, while the other group received a placebo. Height, body weight and percent body fat measurements were obtained at the onset of the study and sixteen weeks later. Results did not indicate any differences in measures of body composition between the experimental (chromium) group and the control (placebo) group. Although the group as a whole lost a small amount of weight, this change was attributed to the implementation of an exercise regimen rather than to chromium supplementation. The authors conclude absolutely no link between body fat, insulin insensitivity, and chromium picolinate, and do not recommend the supplement as a useful aspect of weight-loss programs (Trent & Thieding-Cancel, 1995).

A paper by Grant et al (1997) examined the effects of chromium supplementation in a population of obese women. Subjects took either 200 mcg of chromium picolinate or a placebo with or without exercise training. This particular program that consisted of both cardiovascular and resistance training. In addition, the women were asked not to alter their diets in any way during the course of the study. The dependent measures in the Grant et al (1997) study were body weight, body fat percentage, fat mass, as well as fat free mass. After nine weeks on this program, some interesting findings were revealed. First, the coupling of chromium picolinate and exercise did not produce any significant weight loss as compared to controls, supportive of Trent & Thieding-Cancel (1995) and the general conclusion that chromium picolinate does not enhance weight loss. A second important finding was that chromium supplementation without exercise actually produced a significant increase in body weight. This suggests that chromium picolinate is not only an ineffective tool for weight loss, but may in fact be counterproductive in dieting endeavors (Grant et al, 1997).

A sample of normal males is examined in a third study testing the effects of chromium picolinate on weight loss and body composition (Lukaski et al, 1996). This group was enrolled in a weight training class designed to maximize strength gain in all major muscle groups. Again, the experimental group participated in the exercise program with chromium picolinate supplementation while the control group took a placebo. At the end of an eight week period, both groups were tested for strength, fat-free mass, and muscle mass; while all measures increased as a result of resistance training, there were no significant differences between the experimental and control groups. Additionally, there was no effect on fat loss in either group (Lukaski et al, 1996).

Because chromium picolinate is occasionally marketed to athletes as a natural alternative to steroids, it is pertinent to consider the effects of chromium supplementation within an athlete population. Walker et al (1998) examine body composition and muscular performance of Division I collegiate wrestlers involved in preseason conditioning. The authors point out that “during this phase of training, wrestlers are primarily interested in trying to improve performance…and are not engaged in severe, acute weight loss practices commonly employed before competition” (Walker et al, 1998). Athletes participated in a fourteen week resistance and conditioning schedule. One group’s training was supplemented with chromium picolinate while the other group took placebo tablets. In general agreement with earlier studies, chromium picolinate was not found to decrease body fat or to increase lean muscle mass or strength. This study specifically refutes claims that chromium picolinate produces results analogous to anabolic steroids, and discourages the use of the supplement among athlete populations (Walker et al, 1998). One study did reveal chromium picolinate as an effective aid for weight loss. Harris et al (1998) examined dietary supplementation with Chroma Slim?, a combination pill that includes chromium picolinate and lipotropics such as L-carnitine. The combination of supplementation and exercise significantly increased fat loss as compared to the control group. At present, the results of this study were available only in abstract form and offered only these promising preliminary results (Harris et al, 1998). Several studies using animal subjects also assert fat loss and muscle growth (i.e. Mooney et al, 1995; Lindemann et al, 1995). However, evidence that chromium picolinate can accomplish the same feat in humans is rare, and overwhelmingly indicates that chromium picolinate is simply not effective for human weight loss.

The majority of scientific evidence suggests that chromium picolinate is neither a helpful nor beneficial part of weight loss programs. In the absence of exercise, it may even cause weight gain. An important side note is the fact that all groups involved in chromium picolinate studies, particularly those groups of obese subjects, managed to lose body weight and fat when enrolled in exercise training programs. While chromium picolinate did not enhance weight loss as expected, participants still lost weight and gained muscle by exercising. Although not the easy solution desired by many American dieters, exercise is a proven and safe method to lose weight, to gain muscle, and to improve general health.

Does chromium picolinate have any adverse effects?

Chromium picolinate, though not a proven method of weight loss, remains among the most popular dietary supplements available over the counter. Because it is taken daily by millions of Americans, it is important to evaluate any potential risks involved in chromium supplementation. Unfortunately, there is a scarcity of research concerning these side effects. Several case studies reporting subtle behavioral changes as a result of chromium picolinate are scattered throughout the literature. For example, one patient took chromium picolinate on three separate occasions and had three distinct episodes of “progressively worse cognitive, perceptual, and motor changes” (Krzanowski, 1996). These episodes included sensations of “feeling funny” to reports of mental “short circuiting” and even a complete disruption of motor abilities (Krzanowski, 1996). Other sources report vague symptoms including “irregular heartbeat,” leading the FDA to cite “safety concerns” (http://www.vitawise.com/threehot.htm).

Should you take chromium picolinate?

Despite rampant claims that chromium picolinate is a weight loss miracle that will melt fat, improve metabolism, and increase muscle mass, scientific evidence overwhelmingly indicates that the supplement does nothing of the kind. When combined with exercise, chromium supplementation does nothing to enhance weight loss as compared to exercise alone, in study after study. The case of chromium picolinate should caution consumers against believing miracle weight loss claims. When advertised on the internet, chromium picolinate is presented as a reliable, safe, and fast way to reduce body fat: actual evidence presents a very different picture of this supplement. Taking a daily dose of chromium picolinate will not likely produce any drastic results, and certainly will not produce effects that could not be achieved with exercise alone. Consumers should always be wary of dietary supplements touted as “miracles,” and investigate the truth behind the claims before deciding to take any nutritional aid.

What is the positive scientific data on Chromium?

Chromium facilitates the conversion of blood glucose to glycogen by insulin. Glycogen is stored in the liver and muscles. In the liver, low glycogen levels may result in low blood glucose levels. This can cause fatigue, mental fatigue, inability to concentrate, and light-headedness. The glycogen stored in the skeletal muscles is used for strenuous physical activities. When competitive athletes refer to "hitting the wall" at their exhaustion point, they are referring to the point at which the body's muscle glycogen stores are depleted, resulting in mental and physical exhaustion. Because of its ability to increase liver and muscle glycogen stores, chromium is listed as one of the 33 ergogenic substances considered unethical or illegal by the International Olympic Committee which when taken orally, may increase muscle levels of creatine phosphate and enhance energy performance and exercise performance. [Williams, MH. The use of nutritional ergogenic aids in sports: Is it an ethical issue? International Journal of Sports Nutrition 1994;4:120-131.]

Insulin is the body's primary anabolic hormone. Insulin is a hormone produced by the islet cells of the pancreas that regulates blood sugar levels, and is essential for the proper metabolism of glucose sugar. A reduction in the production of insulin by the pancreas often results in diabetes. Insulin regulates blood sugar levels which can influence overall health, mood, and body weight. Insulin also helps to regulate appetite. Low blood glucose levels which may result from chromium deficiency, can increase appetite. Chromium is necessary for insulin to convert blood glucose into glycogen. Chromium enhances the body's sensitivity or responsiveness to insulin and facilitates the absorption of glucose and protein and the metabolism of fat. Insulin-dependent diabetics should take chromium supplementation only under a physician's supervision because improvements in insulin sensitivity may necessitate adjustments in insulin doses. Chromium theoretically helps insulin transport glucose and amino acid molecules inside the cells for energy production and tissue synthesis. Chromium binds insulin to a special receptor site on cellular membranes, and research has demonstrated that a lack of chromium can cause insulin resistance in both human clinical and isolated tissue studies. When tissues become highly resistant to insulin, the level of insulin in the blood rises, which stimulates the increased storage of fat. The increased storage of fat occurs because insulin increases the activity of a fat storage enzyme, adipose tissue lipoprotein lipase (AT-LPL). AT-LPL transports fat molecules into fat cells, and the higher the insulin levels, the more fat which is transported into the cell. Because chromium increases tissue sensitivity to insulin, it decreases insulin levels in the body, and subsequently decreases fat storage in the tissues.

Pyridoxine, chromium, and tryptophan are recognized as serotonin potentiators. Because serotonin potentiators theoretically act as partial antidepressants, 1255 they may be beneficial in the treatment of depression by reducing the anxiety/aggressive component of the depressive syndrome. The amino acid tryptophan is a serotonin precursor, and supplements or foods rich in tryptophan boost serotonin levels in the brain. Paradoxically, diets high in carbohydrates increase blood serotonin levels more effectively that diets rich in protein foods. Starchy and sweet foods increase blood glucose levels, which trigger the pancreas to release insulin. Insulin increases cellular permeability to glucose and lowers blood glucose levels as glucose migrates from the blood to the tissues. Similarly, cellular permeability to other amino acids (with the exception of tryptophan) is increased. This reduces blood levels of other competing amino acids, and allows latent blood levels of tryptophan unhindered access to the brain where it is transformed into serotonin. Enterochromaffin cells located in the small intestine detect emetogenic stimuli and release serotonin, which causes nausea and vomiting.

Serotonin is a vasoactive substance, and it is released in the blood following platelet degranulation. Increased levels of serotonin have been associated with a decreased desire for carbohydrate foods, and improved sleep. Decreased levels of serotonin have been associated with the process of aging, insomnia, increased depression and psychological stress. Vitamin B6 is one of the building blocks involved in the production of serotonin, and deficiencies can result in reduced serotonin levels, and an abnormal craving for carbohydrates. Chromium increases insulin sensitivity, it may contribute to a decrease in appetite by stabilizing blood glucose levels and by facilitating the synthesis of the neurotransmitter serotonin by insulin. Studies have demonstrated that increased levels of serotonin in the brain can facilitate weight loss by lessening hunger pangs, and by creating a sensation of fullness and satisfaction. Chromium facilitates the synthesis of the serotonin by insulin. Because serotonin potentiators such as chromium theoretically act as partial antidepressants, 1255 they may be beneficial in the treatment of depression by reducing the anxiety/aggressive component of the depressive syndrome.

Chromium Part 2

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©2004 Nutritionadvisor, Inc
DISCLAIMER: We make no medical claims regarding our supplements. Our nutritional supplements are not intended to treat or cure any disease. Please contact your physician before embarking on any weight loss or exercise program.


This site was modified to present format on August 5, 2004.
This website was originally Established on November, 7 1997.


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